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| Home/Cosmetic Surgery For Women/Cosmetic Surgery For Men/Plastic Surgery After Massive Weight Loss/Thermage®/Botox®/Skin Care/Injectable Skin Fillers/The Office Privacy/Contact Us/Sitemap |
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| Ramin A. Behmand, M.D. Plastic & Cosmetic Surgery |
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| Correlation of MPTP Neurotoxicity In Vivo With Oxidation Of MPTP By The Brain And Blood-Brain Barrier In Vitro In Five Rat Strains Riachi N.J., Behmand R.A., Harik S.I. We studied 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in 5 strains of rats by assessing mortality and brain monoamine changes after MPTP injections into the internal carotid artery. We then attempted to correlate the differences among rat strains in their susceptibility to MPTP neurotoxicity in vivo with MPTP oxidation by monoamine oxidase (MAO) of the cerebral cortex, striatum, and brain microvessels in vitro. Despite the fact that the carotid route delivers much higher amounts of MPTP to the ipsilateral cerebrum than can be achieved by systemic injections, no significant dopamine depletion occurred in ipsilateral striata of Sprague-Dawley rats (the most resistant strain), but significant reductions of about 40% in striatal dopamine were evident in the more sensitive strains. Decreased striatal dopamine levels in these latter rat strains were associated with increased dopamine turnover. Higher doses of MPTP resulted in acute death. MPTP-induced mortality was not affected, but striatal dopamine depletion was prevented, by MAO inhibition. Differences among rat strains in their susceptibility to MPTP neurotoxicity correlated best with MAO activity in their isolated brain microvessels, but not with MAO activity in their striata or cerebral cortices. These results are consistent with the hypothesis that the rats' resistance to MPTP neurotoxicity is to some extent a property of their unique brain endothelium which has high MAO activity. |
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| 1776 Ygnacio Valley Rd, Suite 108 Walnut Creek, California 94598 Tel: (925) 939-9200 |
| 1776 Ygnacio Valley Rd, Suite 108, Walnut Creek, California 94598 Telephone: (925) 939-9200 Facsimile: (925) 939-9205 Home/Cosmetic Surgery For Women/Cosmetic Surgery For Men/Plastic Surgery After Massive Weight Loss/Thermage®/Botox®/Skin Care/Injectable Skin Fillers/The Office Privacy/Contact Us/Sitemap |