Hypoxia Increases Glucose Transporter At The Blood-Brain-Barrier- Abstract

Hypoxia Increases Glucose Transport At
Blood-Brain Barrier In Rats

Harik S.I., Behmand R.A., LaManna J.C.

Prolonged hypoxia causes several adaptive changes in systemic
physiology and tissue metabolism. We studied the effects of
hypobaric hypoxia on glucose transport at the blood-brain
barrier (BBB) in the rat. We found that hypoxia increased the
density of brain microvessels seen on immunocytochemical
stains using an antibody to the glucose transporting protein
GLUT. In addition, we found that hypoxia increased the density
of GLUT in isolated cerebral microvessels as determined by
specific cytochalasin B binding. The higher GLUT density in
isolated cerebral microvessels was evident after 1 wk of hypoxia
and was associated with decreased activity of
gamma-glutamyltranspeptidase. Consistent with these findings,
we also demonstrated that 3 wk of hypobaric hypoxia caused
increased unidirectional transport of glucose at the BBB in
several brain regions in vivo, as determined by the doubly
labeled single-pass indicator-fractionation atrial bolus injection
method in anesthetized rats. We conclude that chronic
hypobaric hypoxia is associated with increased glucose transport
at the BBB.

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